Spike Proteins enter The BRAIN causing Inflammation Of Lewy bodies (Alzheimers) & Spongiform Encephalopathy (Mad Cow Disease) In 5-6 weeks in Animal Studies

Spike Proteins enter The BRAIN causing Inflammation Of Lewy bodies (Alzheimers) & Spongiform Encephalopathy (Mad Cow Disease) In 5-6 weeks in Animal Studies

I have not been paying much attention to the connections of spike proteins from mRNA with prions.  Most of the information has come from Kevin McCain who is referenced here. Unfortunately he hasn’t written a word but does over-long, rambling videos. He has also been banned on Twitter and practically expunged from every platform but has a following of his own.

Here is a short version of what Dr Fleming has to say.

Dr.Fleming is no exactly a nobody. Here is his bio.

Bio: In 1994, Dr. Fleming presented to the American Heart Association his “theory” that cardiovascular disease was due to inflammation.  What was a theory in 1994 has become well-known fact for decades and was highlighted in 2004. The Fleming Method patent (FMTVDM) covers ALL methods and devices able to measure metabolic and regional blood flow differences. This breakthrough made it possible to differentiate functionality of tissue, tissue types as well as non-tissue, and the measurement of treatment response using all isotopes, enhancing agents, and devices capable of detecting and measuring isotopes. 

Here he is interviewed by Del Bigtree on the HIghwire

4 June, 2021

 

Dr. Fleming research indicates worst possible outcome for Covid infection/Vaccine. Possible Prion disease and Lewy Bodies leading to Dementia then Death. Can anyone verify this? (Or studies that say otherwise)

Another user linked me a comment about peer reviewed medical journals that indicated in separate animal studies lead to Lewy Body formation (which is the 2nd leading cause of Dementia behind Alzheimer’s).

I guess I never put 2 and 2 together from people saying they have “Covid brain”. This whole time I’ve been focused on other side effects such as infertility, or just general vaccine worries from an untested product.

Here is the copy of the text:

Dementia, then Death.

First: Research out of the Netherlands show that rhesus monkey got Lewy Bodies in their brains after being infected with the virus. Lewy body are form by prions and are the 2nd cause of dementia after Alzheimer’s.

https://21a86421-c3e0-461b-83c2-cfe4628dfadc.filesusr.com/ugd/659775_ebca38540f7e4273a73e6b6e26a51be0.pdf

This paper is currently undergoing peer review as confirmed to me by one of the authors Dr Ingrid Philipens.

Second: research done by Dr Classen and another done by Dr Tetz seem to point the possible origin of the prion making structure to the Spike protein.

https://21a86421-c3e0-461b-83c2-cfe4628dfadc.filesusr.com/ugd/659775_f8f570e6836f414cb1885edf7220a142.pdf

https://scivisionpub.com/pdfs/covid19-rna-based-vaccines-and-the-risk-of-prion-disease-1503.pdf

Now what does it means if true? It means that everyone that got really sick early from covid last year will start developing dementia by this time next year or so (according to Dr Fleming based upon the animals analog in those studies, the estimate is about 2 years, but will vary greatly with natural infection). Next in about 2 years you will see the people that got vaccinated will go through the same thing.”

So that kind of sucks if it turns out to be true in the slightest. It means people who are resisting the vaccine due to natural immunity from short term effects are still screwed from this in a years time anyway. I’m really trying to find some studies that suggest otherwise.

SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988450/Dr,

Danish Idreesa, and Vijay Kumarb,∗∗

Abstract

The post-infection of COVID-19 includes a myriad of neurologic symptoms including neurodegeneration. Protein aggregation in brain can be considered as one of the important reasons behind the neurodegeneration. SARS-CoV-2 Spike S1 protein receptor binding domain (SARS-CoV-2 S1 RBD) binds to heparin and heparin binding proteins. Moreover, heparin binding accelerates the aggregation of the pathological amyloid proteins present in the brain. In this paper, we have shown that the SARS-CoV-2 S1 RBD binds to a number of aggregation-prone, heparin binding proteins including Aβ, α-synuclein, tau, prion, and TDP-43 RRM. These interactions suggests that the heparin-binding site on the S1 protein might assist the binding of amyloid proteins to the viral surface and thus could initiate aggregation of these proteins and finally leads to neurodegeneration in brain. The results will help us to prevent future outcomes of neurodegeneration by targeting this binding and aggregation process.

Keywords: COVID-19, Heparin, Heparin binding proteins, Neurodegeneration, Protein aggregation, SARS-CoV-2

COVID-19 RNA Based Vaccines And The Risk Of Prion Disease

J. BART CLASSEN

 

14 April, 2021

Vaccines have been found to cause a host of chronic, late developing adverse events. Some adverse events like type 1 diabetes may not occur until 3-4 years after a vaccine is administered [1]. In the example of type 1 diabetes the frequency of cases of adverse events may surpass the frequency of cases of severe infectious disease the vaccine was designed to prevent.

Given that type 1 diabetes is only one of many immune mediated diseases potentially caused by vaccines, chronic late occurring adverse events are a serious public health issue.

The advent of new vaccine technology creates new potential mechanisms of vaccine adverse events. For example, the first killed polio vaccine actually caused polio in recipients because the up scaled manufacturing process did not effectively kill the polio virus before it was injected into patients. RNA based vaccines offers special risks of inducing specific adverse events.

One such potential adverse event is prion-based diseases caused by activation of intrinsic proteins to form prions. A wealth of knowledge has been published on a class of RNA binding proteins shown to participating in causing a number of neurological diseases including Alzheimer’s disease and ALS. TDP-43 and FUS are among the best studied of these proteins [2].

 

The Pfizer RNA based COVID-19 vaccine was approved by the US FDA under an emergency use authorization without long term safety data. Because of concerns about the safety of this vaccine, a study was performed to determine if the vaccine could potentially induce prion based disease.

Methods

Pfizer’s RNA based vaccine against COVID-19 was evaluated for the potential to convert TDP-43 and or FUS to their prion-based disease-causing states. The vaccine RNA was analyzed for the presence of sequences that can activate TDP-43 and FUS. The interaction of the transcribed spike protein with its target was analyzed to determine if this action could also activate TDP-43 and FUS.

Results

Analysis of the Pfizer vaccine against COVID-19 identified two potential risk factorsfor inducing prion disease in humans. The RNA sequence in the vaccine [3] contains sequences believed to induce TDP-43 and FUS to aggregate in their prion-based conformation leading to the development of common neurodegerative diseases.

In particular it has been shown that RNA sequences GGUA [4], UG rich sequences [5], UG tandem repeats [6], and G Quadruplex sequences [7], have increased affinity to bind TDP-43 and or FUS and may cause TDP-43 or FUS to take their pathologic configurations in the cytoplasm. In the current analysis, a total of sixteen UG tandem repeats (ΨGΨG) were identified and additional UG (ΨG) rich sequences were identified.

Two GGΨA sequences were found. G Quadruplex sequences are possibly present but sophisticated computer programs are needed to verify these.

The spike protein encoded by the vaccine binds angiotensin converting enzyme 2 (ACE2), an enzyme which contains zinc molecules [8]. The binding of spike protein to ACE2 has the potential to release the zinc molecule, an ion that causes TDP-43 to assume its pathologic prion transformation [9].

Discussion

There is an old saying in medicine that “the cure may be worse than the disease.” The phrase can be applied to vaccines. In the current paper, the concern is raised that the RNA-based COVID vaccines have the potential to cause more disease than the epidemic of COVID-19.

This paper focuses on a novel potential adverse event mechanism causing prion disease which could be even more common and debilitating than the viral infection the vaccine is designed to prevent. While this paper focuses on one potential adverse event, there are multiple other potential fatal adverse events as discussed below.

Over the last two decades there has been a concern among certain scientists that prions could be used as bioweapons. More recently there has been a concern that ubiquitous intracellular molecules could be activated to cause prion disease, including Alzheimer’s disease, ALS and other neurodegenerative diseases.

This concern originates due to potential for misuse of research data on the mechanisms by which certain RNA binding proteins like TDP-43, FUS and others can be activated to form disease causing prions. The fact that this research, which could be used for bioweapons development, is funded by private organizations including the Bill and Melinda Gates Foundation, and Ellison Medical Foundation [2] without national/international oversight is also a concern.

In the past, for example, there were prohibitions for publishing information pertaining to construction of nuclear bombs.

Published data has shown that there are several different factors that can contribute to the conversion of certain RNA binding proteins including TDP-43, FUS and related molecules to their pathologic states. These RNA binding proteins have many functions and are found in both the nucleus and the cytoplasm. These binding proteins have amino acid regions, binding motifs that bind specific RNA sequences.

Binding to certain RNA sequences when the proteins are in the cytoplasm is believed to causes the molecules to fold in certain ways leading to pathologic aggregation and prion formation in the cytoplasm [2]. The current analysis indicates Pfizer’s RNA based COVID-19 vaccine contains many of these RNA sequences that have been shown to have high affinity for TDP-43 or FUS and have the potential to induce chronic degenerative neurological diseases. Zinc binding to the RNA recognition motif of TDP-43 is another mechanism leading to formation of amyloid like aggregations [9].

The viral spike protein, coded by the vaccine RNA sequence, binds ACE2 an enzyme containing zinc molecules [8]. This interaction has the potential to increase intracellular zinc levels leading to prion disease. The initial binding could be between spike proteins on the surface of the cell transfected by the vaccine and ACE2 on the surface of an adjacent cell.

The resulting complex may become internalized. Alternatively, the interaction could initially take place in the cytoplasm of a cell that makes ACE2 and has been transfected with the vaccine RNA coding for the spike protein. The interaction is quite concerning given the belief that the virus causing COVID-19, SARS-CoV-2, is a bioweapon [10,11] and it is possible that the viral spike protein may have been designed to cause prion disease.

Another related concern is that the Pfizer vaccine uses a unique RNA nucleoside 1-methyl-3′-pseudouridylyl (Ψ).

According to FDA briefing documents, this nucleoside was chosen to reduce activation of the innate immune system [12]. RNA molecules containing this nucleoside will undoubtedly have altered binding [13]. Unfortunately, the effect on TDP-43, FUS and other RNA binding proteins is not published. The use of this nucleoside in a vaccine can potentially enhance the binding affinity of RNA sequences capable of causing TDP-43 and FUS to assume toxic configurations.

There are many other potential adverse events that can be induced by the novel RNA based vaccines against COVID-19. The vaccine places a novel molecule, spike protein, in/on the surface of host cells. This spike protein is a potential receptor for another possibly novel infectious agent.

If those who argue that the COVID-19 is actually a bioweapon are correct, then a second potentially more dangerous virus may be released that binds spike protein found on the host cells of vaccine recipients. Data is not publicly available to provide information on how long the vaccine RNA is translated in the vaccine recipient and how long after translation the spike protein will be present in the recipient’s cells.

Such studies pertaining to in vivo expression will be complex and challenging. Genetic diversity protects species from mass casualties caused by infectious agents. One individual may be killed by a virus while another may have no ill effects from the same virus. By placing the identical receptor, the spike protein, on cells of everyone in a population, the genetic diversity for at least one potential receptor disappears.

Everyone in the population now becomes potentially susceptible to binding with the same infectious agent.

Autoimmunity and the opposing condition, metabolic syndrome, are well know adverse events caused by vaccines [14]. COVID-19 infections are associated with the induction of autoantibodies and autoimmune disease [15,16] making it more than plausible a vaccine could do the same.

One author has found amino acid sequences coded by the spike protein to be identical to sequences in human proteins, including proteins found in the CNS [17]. Autoimmunity can also be induced by epitope spreading when a foreign antigen, like the spike protein, is presented by an antigen presenting cell that also has self molecules attached to its MHC molecules.

Finally, others working in the field have published additional support that COVID-19 vaccines could potentially induce prion disease. Authors [18] found prion related sequences in the COVID-19 spike protein which were not found in related coronaviruses. Others [19] have reported a case of prion disease, Creutzfeldt-Jakob disease, initially occurring in a man with COVID-19.

Many have raised the warning that the current epidemic of COVID-19 is actually the result of an bioweapons attack released in part by individuals in the United States government [10,11]. Such a theory is not far fetched given that the 2001 anthrax attack in the US originated at Fort Detrick, a US army bioweapon facility.

Because the FBI’s anthrax investigation was closed against the advice of the lead FBI agent in the case, there are likely conspirators still working in the US government. In such a scenario, the primary focus of stopping a bioweapons attack must be to apprehend the conspirators or the attacks will never cease.

Approving a vaccine, utilizing novel RNA technology without extensive testing is extremely dangerous. The vaccine could be a bioweapon and even more dangerous than the original infection.

Source

References

  1. Classen JB, Classen DC. Clustering of cases of insulin dependent diabetes (IDDM) occurring three years after Hemophilus influenza B (HiB) immunization support causal relationship between immunization and IDDM. Autoimmunity. 2002; 35: 247-253.
  2. King OD, Gitler AD, Shorter J. The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease. Brain Res. 2012; 1462: 61-80.
  3. WHO, International Non Proprietary Names Program: 11889. 9/2020.
  4. Kapeli K, Pratt GA, Vu AQ, et al. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. Nature Communications. 2016; 7: 12143.
  5. Kuo P, Chiang C, Wang Y, et al. The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids. Nucleic Acids Research. 2014; 42: 4712-4722.
  6. Tollervey JR, Curk T, Rogelj B, et al. Characterizing the RNA targets and position-dependent splicing regulation by TDP-43; implications for neurodegenerative diseases. Nat Neurosci. 2011; 14: 452-458.
  7. Imperatore JA, McAninch DS, Valdez-Sinon AN, et al. FUS recognizes G quadruplex structures within neuronal mRNAs. Frontiers in Molecular Biosciences. 2020; 7: 6.
  8. Shang J, Ye G, Shi K, et al. Structural basis of receptor recognition by SARS-CoV-2. Nature. 2020; 581: 221-225.
  9. Garnier C, Devred F, Byrne D, et al. Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates. Sci Rep. 2017; 7: 6812.
  10. Classen JB. COVID-19, MMR vaccine, and bioweapons. Diabetes & its Complications.2020; 4: 1-8.
  11. Classen JB. Evidence supporting the hypothesis that the 2019 epidemic of E-vaping acute lung injury (EVALI) was caused in part by COVID-19. Diabetes & Complications. 2020; 4: 1-2.
  12. Pfizer-Biotech: COVID-19 Vaccine (BNT162, PF-07302048), Vaccines and Related Biological Products Advisory Committee Briefing Document. Meeting Date: 10 December 2020.
  13. Roundtree IA, Evans ME, Pan, et al. Dynamic RNA modifications in gene expression regulation. Cell. 2017; 169: 1187-1200.
  14. Classen JB. Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent accelerations in the Risk of Prediabetes and other Immune Mediated Diseases. J Mol Genet Med. 2014; S1: 025.
  15. Amiral J. Can COVID-19 Induce an autoimmune disease associated with long- lasting symptoms and delayed complications? Ann Clin Immunol Microbiol. 2020; 2: 1014.
  16. Wang EY, Mao T, Klein J, et al. Diverse functional autoantibodies in patients with COVID-19. medRxiv preprint. 2020.
  17. Lyons-Weiler J. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. Journal of Translational Autoimmunity. 2020; 3: 100051.
  18. Tetz G, Tetz V. SARS-CoV-2 prion-like domains in spike proteins enable higher affinity to ACE2. Preprint. 2020.
  19. Young MJ, O’Hare M, Matiello M, et al. Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neuro degeneration? Brain, Behavior, and Immunity. 2020; 89: 601-603

Read more here: scivisionpub.com

COVID19 is an aerosolized Prion Disease

Some useful Twitter accounts: https://twitter.com/Parsifaler and https://twitter.com/KevinMccairn

Useful youtube channel/video run by established Neuroscientist Dr. Kevin McCairn who is postulating the hypothesis: https://twitter.com/KevinMccairn/status/1361069854258728960?s=20

His response to a recent paper (from this week) on COVID inducing Lewy body buildup: https://twitter.com/KevinMccairn/status/1364643610826743808?s=20

This is a very new theory. COVID was first speculated to be purely a respiratory disease that induces pneumonia. Then new evidence emerged that it was inducing hypoxia (oxygen deprivation), so they updated COVID to a cardiovascular disease. Then later in 2020, they found patients with severe neurological problems so they started to say COVID was also a neurological disease. Dr McCairn is leading the way in the research on the neurological effects of COVID. His hypothesis is that COVID is a prion disease. He believes virologists are wholly out of their depth when discussing the neuroscience, and he believes they are getting the vaccine strategy all wrong. The implications of an aerosolized prion disease are potentially catastrophic, and at worst it could maybe even be an extinction level event.

Here are his credentials: https://www.linkedin.com/in/dr-kevin-mccairn-phd-619b411a/?originalSubdomain=uk and https://www.researchgate.net/profile/Kevin-Mccairn

Other relevant sources: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612014000300001 and https://discord.com/invite/5Pydnfn (his discord)

If covid were a prion bioweapon, how would this change things in regard to prepping? The scientist here is recommending people boil their water as prions accumulate in waste water and then flow through the taps. I’d love to hear everyone’s thoughts. Thanks.

SARS-CoV-2 An Aerosolized Prion Disease – And Potential Symptomatic Profile

0:00 Kev’s qualifications

11:40 COVID overview 16:00 Establishing Koch’s postulates for COVID19

19:40 Wuhan lab leak 24:00 COVID CNS penetration

27:50 Gain of function and furin clevage site 31:00 How COVID attacks the nervous system

37:05 evidence via monkey experimentation

56:33 START OF PRION EVIDENCE

1:12:39 Prion paper from 2018

1:15:52 Types of viruses that have prion binding domains (SARS-CoV-2 is one!)

1:19:33 Evidence Sars-CoV-2 highly unlikely to be of natural origin

1:24:05 Modelling Tourettes ticks in monkeys

1:26:40 Induced parkinsonian symptoms in monkeys

1:36:07 Hypokinetic condition – Basal ganglia and iron metabolisation

1:38:20 outro/Q&A

Join our Discord https://discord.gg/qeuuRBF
Not everyone agrees on this.

Next Wave Ep5 (Prions are not an issue in this crisis) by Dr. Paul Cottrell

Chris Robertson, Professor of public health epidemiology, University of Strathclyde, said that adjusting for age and comorbidities, the Delta variant roughly doubled the risk of hospitalisation, but vaccines still reduced that risk.

“If you test positive, then two doses of the vaccine or one dose for 28 days roughly reduces your risk of being admitted to hospital by 70 percent,” he told reporters.

Two weeks after the second dose, Pfizer-BioNTech’s vaccine was found to have 79 percent protection against infection from the Delta variant, compared to 92 percent against the Alpha variant. For Oxford-AstraZeneca’s vaccine, there was 60 percent protection against Delta compared with 73 percent for Alpha.

The researchers cautioned against using the data to compare the vaccines against each other due to differences in the cohorts which received each type of shot, and differences in how quickly immunity is developed with each shot.

They said two doses of vaccine provide much better protection than one dose against the Delta variant, and a delay to easing lockdown in England would help more people get second doses and for their immune responses to build up.

https://www.newshub.co.nz/home/world/2021/06/coronavirus-delta-covid-variant-doubles-risk-of-serious-illness-but-vaccines-reduce-risk-study.html

How are we to validly compare the above information with this?

Are you going to risk your life to avoid a stiff cold?

Leave a Reply

Your email address will not be published.

Wordpress Social Share Plugin powered by Ultimatelysocial
RSS