Risk of Prion Disease in mRNA Vaccine
COVID-19 RNA Based Vaccines and the Risk of Prion Disease.
Classen Immunotherapies, Inc. J Bart Classen, MD. – Jan 2021.
Abstract: Development of new vaccine technology has been plagued with problems in the past. The current RNA based SARSCoV-2 ‘vaccines’ were ‘approved’ in the US using an ‘Emergency Order’ without extensive long term safety testing. In this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce Prion-Based Disease in ‘vaccine’ recipients. The RNA sequence of the ‘vaccine’ as well as the spike protein target interaction were analysed for the potential to convert intracellular RNA binding proteins TAR DNA Binding Protein (TDP-43) and Fused in Sarcoma (FUS) into their Pathologic Prion Conformations. The results indicate that the ‘vaccine’ RNA has specific sequences that may induce TDP-43 and FUS to fold into their pathologic prion conformations. In the current analysis a total of sixteen UG tandem repeats (ΨGΨG) were identified and additional UG (ΨG) rich sequences were identified. Two GGΨA sequences were found. Potential G Quadruplex sequences are possibly present but a more sophisticated computer programme is needed to verify these. Furthermore, the Spike Protein, created by the translation of the ‘vaccine’ RNA, binds Angiotensin Converting Enzyme 2 (ACE2), a Zinc containing enzyme. This interaction has the potential to increase intracellular zinc. Zinc ions have been shown to cause the transformation of TDP-43 to its Pathologic Prion Configuration. The folding of TDP-43 and FUS into their Pathologic Prion Conformations is known to cause ALS (Amyotrophic Lateral Sclerosis), Frontotemporal Lobar Degeneration, Alzheimer’s Disease and other Neurological Degenerative Diseases. The enclosed finding as well as additional potential risks leads the author to believe that regulatory approval of the RNA based ‘vaccines’ for SARS-CoV-2 was premature and that the ‘vaccine’ may cause much more harm than benefit.
Introduction (extracts): ‘Vaccines’ have been found to cause a host of chronic, late developing adverse events. Some adverse events like Type 1 Diabetes may not occur until 3-4 years after a ‘vaccine’ is administered. In the example of Type 1 Diabetes the frequency of adverse events may surpass the frequency of cases of severe infectious disease the ‘vaccine’ was ‘designed’ to prevent. Given that Type 1 Diabetes is only one of many immune mediated diseases potentially caused by ‘vaccines,’ chronic late occurring adverse events are a serious public health issue. The advent of new ‘vaccine’ technology creates new potential mechanisms of ‘vaccine’ adverse events. For example, the first killed Polio ‘vaccine’ actually caused Polio in recipients because the up scaled manufacturing process did not effectively kill the Polio virus before it was injected into patients. RNA based ‘vaccines’ offer special risks of inducing specific adverse events. One such potential adverse event is Prion based diseases caused
by activation of intrinsic proteins to form Prions. A wealth of knowledge has been published on a class of RNA Binding Proteins shown to participating in causing a number of neurological diseases including Alzheimer’s Disease and ALS. TDP-43 and FUS are among the best studied of these proteins. The Spike Protein encoded by the ‘vaccine’ binds Angiotensin Converting Enzyme 2 (ACE2), an enzyme which contains Zinc molecules. The binding of Spike Protein to ACE2 has the potential to release the Zinc molecule, an ion that causes TDP-43 to assume its Pathologic Prion Transformation.
Discussion (extracts): ‘The Cure May be Worse than the Disease.’ Over the last two decades there has been a concern among certain scientists that Prions could be used as Bioweapons. More recently there has been a concern that ubiquitous intracellular molecules could be activated to cause Prion Disease including Alzheimer’s Disease, ALS and other Neurodegenerative Diseases. This concern originates due to potential for misuse of research data on the mechanisms by which certain RNA binding proteins like TDP-43, FUS and others can be activated to form disease causing Prions. The fact that this research, which could be used for bioweapons development, is funded by private organisations including the Bill and Melinda Gates Foundation, and Ellison Medical Foundation without National/International oversight is also a concern. Published data has shown that there are several different factors that can contribute to the conversion of certain RNA Binding Proteins including TDP-43, FUS and related molecules to their Pathologic states. These RNA Binding Proteins have many functions and are found in both the (cell) Nucleus and the Cytoplasm. These Binding Proteins have amino acid regions, binding motifs that bind specific RNA sequences. Binding to certain RNA sequences when the proteins are in the Cytoplasm is believed to cause the molecules to fold in certain ways leading to Pathologic Aggregation and Prion formation in the Cytoplasm. The current analysis indicates Pfizer’s RNA based COVID-19 ‘vaccine’ contains many of these RNA sequences that have been shown to have high affinity for TDP-43 or FUS and have the potential to induce chronic degenerative neurological diseases. ‘… quite concerning given the belief that the virus causing COVID-19, SARS-CoV-2, is a Bioweapon and it is possible that the Viral Spike Protein may have been designed to cause Prion Disease.’ Another related concern is that the Pfizer vaccine uses a unique RNA nucleoside 1-methyl-3′-pseudouridylate (Ψ). According to FDA briefing documents, this nucleoside was chosen to reduce activation of the innate immune system. RNA molecules containing this nucleoside will undoubtedly have altered binding. Unfortunately, the effect on TDP-43, FUS and other RNA Binding Proteins is not published. The use of this nucleoside in a ‘vaccine’ can potentially enhance the binding affinity of RNA sequences capable of causing TDP-43 and FUS to assume toxic configurations.
There are many other potential adverse events that can be induced by the novel RNA based ‘vaccines’ against COVID-19. The ‘vaccine’ places a novel molecule, Spike Protein, in/on the surface of host cells. This Spike Protein is a potential receptor for another possibly novel infectious agent. If those who argue that the COVID-19 is actually a Bioweapon are correct, then a second potentially more dangerous virus may be released that binds Spike Protein found on the host cells of ‘vaccine’ recipients. Data is not publicly available to provide information on how long the ‘vaccine’ RNA is translated in the ‘vaccine’ recipient and how long after translation the Spike Protein will be present in the recipient’s cells. Genetic diversity protects species from mass casualties caused by infectious agents. One individual may be killed by a virus while another may have no ill effects from the same virus. By placing the identical receptor (the spike protein) on cells of everyone [via a ‘vaccine’] in a population, the genetic diversity for at least one potential receptor disappears. Everyone in the population now becomes potentially susceptible to binding with the same infectious agent. Autoimmunity and the opposing condition, Metabolic Syndrome, are well known adverse events caused by ‘vaccines.’ COVID-19 infections are associated with the induction of autoantibodies and autoimmune disease making it more than plausible a ‘vaccine’ could do the same. One author has found amino acid sequences coded by the Spike Protein to be identical to sequences in human proteins including proteins found in the CNS (Central Nervous System). Autoimmunity can also be induced by epitope spreading when a foreign antigen, like the Spike Protein, is presented by an antigen presenting cell that also has self molecules attached to its MHC (Major Histocompatibility Complex) molecules. Others working in the field have published additional support that COVID-19 ‘vaccines’ could potentially induce Prion disease. Authors found Prion Related Sequences in the COVID-19 Spike Protein which were not found in related Coronaviruses. Others have reported a case of Prion disease, Creutzfeldt-Jakob disease, initially occurring in a man with COVID-19 [Variant Creutzfeldt–Jakob disease (vCJD) is a type of Brain disease within the transmissible Spongiform Encephalopathy family. Initial symptoms include psychiatric problems, behavioural changes, and painful sensations].