We now have the technology to develop vaccines that spread themselves

We now have the technology to develop vaccines that spread themselves

“Selfspreading vaccines are genetically engineered to move through populations like communicable diseases, but rather than causing disease, they confer protection. The vision is that a small number of individuals in a target population could be vaccinated, and the vaccine strain would then circulate in the population much like a pathogenic virus, resulting in rapid, widespread immunity.”
Prevention is better than cure, so we should start using genetic techniques to stop dangerous animal diseases jumping to humans, say Scott Nuismer and James Bull
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Michelle D’Urbano

New Scientist,

19 August, 2021

 

A FAMOUS quote often attributed to Benjamin Franklin is “an ounce of prevention is worth a pound of cure”. The world is now discovering the cost of its pound of cure for covid-19. But what would an ounce of prevention look like?

For infectious diseases that originate in wild animals, like covid-19, SARS, MERS and Ebola, one solution is to prevent the transmission to humans in the first place. To achieve this, an important first step is to change our behaviour to reduce contact with the wildlife species that harbour such diseases.

A complementary approach is to target the infectious agents that carry these diseases by reducing their prevalence or eliminating them within wildlife populations. Although this isn’t a new idea, advances in technology mean we may have a better chance of it succeeding than ever before.

The classic example of this is rabies: we vaccinate dogs and many wild carnivores to suppress rabies in those populations and so reduce our own risk of catching it. Although these vaccination campaigns have virtually eliminated human rabies in the US and Europe, the disease still kills more than 55,000 people annually across Africa and Asia, where the cost of wildlife vaccination projects is a barrier to maintaining a sufficient level of immunity

Using wildlife vaccination to target other dangerous pathogens that circulate within bats and rodents – such as Ebola, Marburg, SARS and Lassa viruses – faces similar obstacles, which is compounded by the rapid population turnover and large population sizes of these animals.

A possible solution is to create vaccines that spread themselves through an animal population.

These “self-disseminating vaccines” can be developed in at least two ways. The conventional approach relies on applying a vaccine to the fur of captured animals and releasing them. When these animals return to their natural homes, social grooming results in the vaccine being ingested by other individuals, magnifying the level of immunity that can be achieved.

This shows promise for reducing the threat of rabies transmitted to humans from vampire bats, for example.

A more radical approach relies on inserting a small piece of the genome of the infectious disease agent into a benign virus that spreads naturally through the animal population. As this transmissible vaccine spreads from animal to animal, it immunises them against the target infectious disease, vastly increasing immunity within the animal population and reducing the risk of spillover to humans.

The technology for developing transmissible vaccines now exists, and field trials focused on protecting wild rabbits from a viral haemorrhagic fever using this technique have showed promising results. Efforts are now under way to develop prototypes for several important human pathogens, such as the Lassa and Ebola viruses.

Self-disseminating vaccines could be a revolutionary technology for reducing the threat of human infectious diseases that jump to us from wild animals. In addition to making wildlife vaccination feasible and cost-effective, this technology reduces the motivation to cull or exterminate ecologically important disease reservoir species, such as bats.

However, there is still much work to do. Lab and field trials need to check how effective this approach is and look for possible unexpected consequences of
self-disseminating vaccines. But as the costs of our ongoing attempts to find a “cure” for covid-19 continue to accumulate, an ounce of prevention seems to be a better investment with each passing day.

Read more: https://www.newscientist.com/article/mg24732960-100-we-now-have-the-technology-to-develop-vaccines-that-spread-themselves/#ixzz6tmdBKoyg

Were COVID-19 Vaccines Made To “Self-Spread” To Non-Vaccinated People?

Documents from Pfizer, Johns Hopkins and others discuss the potential for COVID-19 vaccines to “self-spread” to non-vaccinated individuals coming in contact with a recently vaccinated person

In fact, a 2018 report by Johns Hopkins Bloomberg School of Public Health’s Center for Health Security floated the idea of using this type of vaccine to intentionally spread to others for “protection” against disease.

Under the section, “Self-Spreading Vaccines,” the Johns Hopkins document states, “Selfspreading vaccines are genetically engineered to move through populations like communicable diseases, but rather than causing disease, they confer protection. The vision is that a small number of individuals in a target population could be vaccinated, and the vaccine strain would then circulate in the population much like a pathogenic virus, resulting in rapid, widespread immunity.”

The paper admits self-spreading vaccines being implemented would come with challenges, such as “informed consent” and potentially life-threatening contraindications.

“The ethical and regulatory challenges surrounding informed consent and prevention and monitoring of adverse events would be critical challenges to implementing this approach even in an extreme event,” the document states.

Read the article HERE

 

Read the paper HERE

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